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Article

Effects of SCN1A and SCN2A polymorphisms on responsiveness to valproic acid monotherapy in epileptic children: A protocol for systematic review and meta-analysis.

Medicine - 21 May 2021

Wen Zhuangfei, Chen Jiang, Zhu Bin, Lu Yan, Chen Lijiao

Abstract excerpt

BACKGROUND: : The gene mutation of coding sodium channel is one of the most important mechanisms in the pathogenesis of epilepsy. There exists a large inter-individual variation in the efficacy of valproic acid (VPA) against epilepsy. What are the genetic polymorphism influences of sodium channels on VPA response is still under discussion. In this study, a meta-analysis was used to further explore the effects of...

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Identifiers

PMID: 34011048
DOI: 10.1097/MD.0000000000025831
PMCID: PMC8136989

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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