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Article

Switchable reinforced streptavidin.

Nanoscale - 28 Mar 2020

Schendel Leonard C, Sedlak Steffen M, Gaub Hermann E

Abstract excerpt

The complex of the small molecule biotin and the homotetrameric protein streptavidin is key to a broad range of biotechnological applications. Therefore, the behavior of this extraordinarily high-affinity interaction under mechanical force is intensively studied by single-molecule force spectroscopy. Recently, steered molecular dynamics simulations have identified a low force pathway for the dissociation of...

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Identifiers

PMID: 32181776
DOI: 10.1039/d0nr00265h

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