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Article

The Puzzle of Hereditary Spastic Paraplegia: From Epidemiology to Treatment.

International journal of molecular sciences - 11 Jul 2022

Meyyazhagan Arun, Kuchi Bhotla Haripriya, Pappuswamy Manikantan, Orlacchio Antonio

Abstract excerpt

Inherited neurodegenerative pathology characterized by lower muscle tone and increasing spasticity in the lower limbs is termed hereditary spastic paraplegia (HSP). HSP is associated with changes in about 80 genes and their products involved in various biochemical pathways, such as lipid droplet formation, endoplasmic reticulum shaping, axon transport, endosome trafficking, and mitochondrial function. With the...

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Source

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Identifiers

PMID: 35887006
DOI: 10.3390/ijms23147665
PMCID: PMC9321931

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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