Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ubiquitination of renal ENaC subunits in vivo.

American journal of physiology. Renal physiology - 1 May 2020

Frindt Gustavo, Bertog Marko, Korbmacher Christoph, Palmer Lawrence G

Abstract excerpt

Ubiquitination of the epithelial Na+ channel (ENaC) in epithelial cells may influence trafficking and hormonal regulation of the channels. We assessed ENaC ubiquitination (ub-ENaC) in mouse and rat kidneys using affinity beads to capture ubiquitinated proteins from tissue homogenates and Western blot analysis with anti-ENaC antibodies. Ub-αENaC was observed primarily as a series of proteins of apparent molecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aldosterone
Share to Epithelial Sodium Channels
Share to Kidney

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Proteolysis

Share to Rats, Sprague-Dawley

Share to Ubiquitination

Source

Open in PubMed Open full text

Identifiers

PMID: 32174140
DOI: 10.1152/ajprenal.00609.2019
PMCID: PMC7294337

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ubiquitination of renal ENaC subunits in vivo.PMID 32174140Read ↗

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.Semantic proximity Read ↗

Regulation of epithelial sodium channels by the ubiquitin-proteasome proteolytic pathway.Semantic proximity Read ↗

Intracellular ubiquitylation of the epithelial Na+ channel controls extracellular proteolytic channel activation via conformational change.Semantic proximity Read ↗

Nedd4-2 catalyzes ubiquitination and degradation of cell surface ENaC.Semantic proximity Read ↗

Participation of the ubiquitin-conjugating enzyme UBE2E3 in Nedd4-2-dependent regulation of the epithelial Na+ channel.Semantic proximity Read ↗

Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin.Semantic proximity Read ↗

Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.Semantic proximity Read ↗

Nedd4-2 phosphorylation induces serum and glucocorticoid-regulated kinase (SGK) ubiquitination and degradation.Semantic proximity Read ↗

Ubiquitination-activating enzymes UBE1 and UBA6 regulate ubiquitination and expression of cardiac sodium channel Nav1.5.Semantic proximity Read ↗

Short-chain ubiquitination mediates the regulated endocytosis of the aquaporin-2 water channel.Semantic proximity Read ↗

Regulation of the Na-K-2Cl cotransporter NKCC2 by ubiquitylationSemantic proximity Read ↗

WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.