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Article

Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin.

The Journal of biological chemistry - 19 May 2006

Wang Huamin, Traub Linton M, Weixel Kelly M, Hawryluk Mathew J, Shah Nirav, Edinger Robert S, Perry Clint J, Kester Lauren, Butterworth Michael B, Peters Kathryn W, Kleyman Thomas R, Frizzell Raymond A, Johnson John P

Abstract excerpt

Here we present evidence that the epithelial sodium channel (ENaC), a heteromeric membrane protein whose surface expression is regulated by ubiquitination, is present in clathrin-coated vesicles in epithelial cells that natively express ENaC. The channel subunits are ubiquitinated and co-immunoprecipitate with both epsin and clathrin adaptor proteins, and epsin, as expected, co-immunoprecipitates with clathrin...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16574660
DOI: 10.1074/jbc.M512511200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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