Article
In Situ Mannosylated Nanotrinity-Mediated Macrophage Remodeling Combats Candida albicans Infection.
ACS nano - 28 Apr 2020
Gao Qiongqiong, Zhang Jing, Chen Chen, Chen Menglin, Sun Peng, Du Wei, Zhang Shengchang, Liu Ying, Zhang Rui, Bai Mei, Fan Changchun, Wu Jibiao, Men Tongyi, Jiang Xinyi
Abstract excerpt
Deep Candida albicans infection is one of the major causes of death in immunosuppressed hosts. Remodeling macrophages to phenotype M1 can decrease fungus burden and facilitate combating C. albicans under an immunosuppressive state. In this study, a nanotrinity was exploited to direct fungicidal macrophage polarization by leveraging the regulation pathways in macrophage redifferentiation. Conventional...
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