Article
The cytochrome P450 enzyme CYP24A1 increases proliferation of mutant KRAS-dependent lung adenocarcinoma independent of its catalytic activity.
The Journal of biological chemistry - 1 May 2020
Huang Wei, Ray Paramita, Ji Wenbin, Wang Zhuwen, Nancarrow Derek, Chen Guoan, Galbán Stefanie, Lawrence Theodore S, Beer David G, Rehemtulla Alnawaz, Ramnath Nithya, Ray Dipankar
Abstract excerpt
We previously reported that overexpression of cytochrome P450 family 24 subfamily A member 1 (CYP24A1) increases lung cancer cell proliferation by activating RAS signaling and that CYP24A1 knockdown inhibits tumor growth. However, the mechanism of CYP24A1-mediated cancer cell proliferation remains unclear. Here, we conducted cell synchronization and biochemical experiments in lung adenocarcinoma cells, revealing...
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