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Article

CYP24, the enzyme that catabolizes the antiproliferative agent vitamin D, is increased in lung cancer

17 May 2006

Abstract excerpt

1Alpha,25-dihydroxyvitamin D3 (1,25D3) displays potent antiproliferative activity in a variety of tumor model systems and is currently under investigation in clinical trials in cancer. Studies were initiated to explore its potential in nonsmall cell lung cancer (NSCLC), as effective approaches to the treatment of that disease are needed. In evaluating factors that may affect activity in NSCLC, the authors found...

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PMID: 16708384
DOI: 10.1002/ijc.22058

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