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Functional Classification of TP53 Mutations in Acute Myeloid Leukemia

10 Mar 2020

Abstract excerpt

Mutations of the TP53 gene occur in a subset of patients with acute myeloid leukemia (AML) and confer an exceedingly adverse prognosis. However, whether different types of TP53 mutations exert a uniformly poor outcome has not been investigated yet. Here, we addressed this issue by analyzing data of 1537 patients intensively treated within protocols of the German-Austrian AML study group. We classified TP53...

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PMID: 32164171
DOI: 10.3390/cancers12030637

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