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Article

Clinical significance of TP53 mutations in patients with acute myeloid leukemia: the HM-SCREEN-JAPAN 01/02 study.

International journal of hematology - 1 Aug 2026

Ogasawara Fumiya, Minami Yosuke, Chi SungGi, Ueda Tomoaki, Fukushima Kentaro, Kojima Kensuke

Abstract excerpt

Mutant TP53 (mTP53) variants are diverse, and residual wild-type p53 function (functional, non-functional), gain-of-function (GOF) mTP53, and the number of mTP53 (single-hit, multi-hit) can affect prognosis. We used next-generation sequencing to evaluate the association between qualitative and quantitative mTP53 abnormalities and overall survival (OS) in 330 patients with acute myeloid leukemia (AML) enrolled in...

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Identifiers

PMID: 41915141
DOI: 10.1007/s12185-026-04192-4

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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Clinical significance of TP53 mutations in patients with acute myeloid leukemia: the HM-SCREEN-JAPAN 01/02 study.PMID 41915141Read ↗

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