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Article

Transformation from EGFR/PTEN co-mutated lung adenocarcinoma to small cell carcinoma in lymph node metastasis.

Pathology international - 1 May 2020

Hayashi Takuo, Takamochi Kazuya, Kohsaka Shinji, Kishikawa Satsuki, Suehara Yoshiyuki, Takahashi Fumiyuki, Suzuki Kenji, Saito Tsuyoshi, Yao Takashi

Abstract excerpt

There is minimal evidence of EGFR-mutated lung adenocarcinoma transforming to small cell lung carcinoma (SCLC) without the administration of EGFR-tyrosine kinase inhibitor (TKI). Here, we present a case of EGFR/PTEN co-mutated lung adenocarcinoma with lymph node metastases, which comprised adenocarcinoma admixed with SCLC. EGFR L858R and PTEN R130Q mutations were shared between the primary tumor and lymph node...

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Share to Adenocarcinoma of Lung
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphatic Metastasis

Share to Neoplasms, Second Primary

Share to PTEN Phosphohydrolase

Share to Retinoblastoma Binding Proteins

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Source

Identifiers

PMID: 32162763
DOI: 10.1111/pin.12919

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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