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Article

Dishevelled 1-Regulated Superpotent Cancer Stem Cells Mediate Wnt Heterogeneity and Tumor Progression in Hepatocellular Carcinoma.

Stem cell reports - 10 Mar 2020

Liao Wen-Ying, Hsu Chung-Chi, Chan Tze-Sian, Yen Chia-Jui, Chen Wei-Yu, Pan Hung-Wei, Tsai Kelvin K

Abstract excerpt

Various populations of cancer stem cells (CSCs) have been identified in hepatocellular carcinoma (HCC). Wnt signaling is variably activated in HCC and regulates CSCs and tumorigenesis. We explored cell-to-cell Wnt and stemness heterogeneity in HCC by labeling freshly isolated cancer cells with a Wnt-specific reporter, thereby identifying a small subset (0.4%-8.9%) of Wnt-activityhigh cells. Further cellular...

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Source

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Identifiers

PMID: 32160521
DOI: 10.1016/j.stemcr.2020.02.003
PMCID: PMC7066362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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