Article
Germline and somatic mtDNA mutation spectrum of rheumatoid arthritis patients in the Taizhou area, China.
Rheumatology (Oxford, England) - 1 Oct 2020
Du Juping, Yu Sufei, Wang Donglian, Chen Shuaishuai, Chen Suyun, Zheng Yufen, Wang Na, Chen Shiyong, Li Jun, Shen Bo
Abstract excerpt
OBJECTIVE: Reactive oxygen species are believed to be involved in the onset of RA, and the association between nuclear-encoded mitochondrial respiratory chain-related variants and RA has recently been revealed. However, little is known about the landscape of mitochondrial DNA (mtDNA) variants in RA. METHODS: Next-generation sequencing was conducted to profile mtDNA germline and somatic variants in 124 RA patients...
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