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Article

Expression and mutation characteristics of mitochondrial genes in PBMCs of SLE patients: Implications for SLE pathogenesis.

Medicine - 17 Jul 2026

Zhang Suiying, Huang Xinglan, Mai Jingming, Zhang Ning, Wang Xingrong, Zhao Xiaoqing, Deng Yuqiong, Sun Shubing, Cheng Xiping

Abstract excerpt

This study aimed to investigate mitochondrial gene mutations and expression in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematosus (SLE) patients, focusing on MT-ND5, and assess expression changes under lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α), and dexamethasone stimulation. Peripheral blood was collected from female SLE patients. Mitochondrial DNA (mtDNA) from PBMCs was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42470042
DOI: 10.1097/MD.0000000000049806
PMCID: PMC13384613

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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