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Article

Aggregation of rare/low-frequency variants of the mitochondria respiratory chain-related proteins in rheumatoid arthritis patients.

Journal of human genetics - 1 Aug 2015

Mitsunaga Shigeki, Hosomichi Kazuyoshi, Okudaira Yuko, Nakaoka Hirofumi, Suzuki Yasuo, Kuwana Masataka, Sato Shinji, Kaneko Yuko, Homma Yasuhiko, Oka Akira, Shiina Takashi, Inoko Hidetoshi, Inoue Ituro

Abstract excerpt

Exome sequencings were conducted using 59 patients having rheumatoid arthritis (RA) and 93 controls. After stepwise filtering, 107 genes showed less than 0.05 of P-values by gene-burden tests. Among 107 genes, NDUFA7 which is a subunit of the complex I in the mitochondrial respiratory chain was selected for further analysis based on previous reports. A case-control study was performed on the three...

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Share to Arthritis, Rheumatoid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 26016412
DOI: 10.1038/jhg.2015.50

Genes

NDUFA7
SCO1
SDHAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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