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Article

Polymorphisms of the IgH enhancer HS1.2 and risk of systemic lupus erythematosus.

Annals of the rheumatic diseases - 1 Aug 2012

Frezza Domenico, Tolusso Barbara, Giambra Vincenzo, Gremese Elisa, Marchini Maurizio, Nowik Marcin, Serone Eliseo, D'Addabbo Pietro, Mattioli Claudia, Canestri Silvia, Petricca Luca, D'Antona Graziella, Birshtein Barbara K, Scorza Raffaella, Ferraccioli Gianfranco

Abstract excerpt

OBJECTIVE: To determine whether the allelic frequency variation of the HS1.2 enhancer of the immunoglobulin heavy chain (IgH) 3' regulatory region (3'RR-1) locus represents a risk factor for systemic lupus erythematosus (SLE) and to identify a possible functional difference in the two most frequent alleles (*1 and *2) in binding nuclear factor- κB (NF-κB) and Sp1. METHODS: The frequency of the enhancer HS1.2...

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Share to Electrophoretic Mobility Shift Assay
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22294636
DOI: 10.1136/ard.2010.147025

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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