Article
Interactions at a dioxin responsive element (DRE) and an overlapping kappaB site within the hs4 domain of the 3'alpha immunoglobulin heavy chain enhancer.
Toxicology - 5 Aug 2004
Sulentic Courtney E W, Kang Jong Soon, Na Yong Joo, Kaminski Norbert E
Abstract excerpt
Our previous results describing the CH12.LX (AhR-expressing) and BCL-1 (AhR-deficient) B cell lines have supported an AhR/dioxin-responsive element (DRE)-mediated mechanism for TCDD-induced inhibition of micro heavy chain expression and thus of IgM secretion. Transcriptional regulation of the Ig...
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