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Article

Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3' regulatory regions and its conservation in mammals.

Biopolymers - 1 Nov 2016

Sette Marco, D'Addabbo Pietro, Kelly Geoffrey, Cicconi Alessandro, Micheli Emanuela, Cacchione Stefano, Poma Anna, Gargioli Cesare, Giambra Vincenzo, Frezza Domenico

Abstract excerpt

Regulatory regions in the genome can act through a variety of mechanisms that range from the occurrence of histone modifications to the presence of protein-binding loci for self-annealing sequences. The final result is often the induction of a conformational change of the DNA double helix, which alters the accessibility of a region to transcription factors and consequently gene expression. A ∼300 kb regulatory...

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Identifiers

PMID: 27287611
DOI: 10.1002/bip.22891
PMCID: PMC5516150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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