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The functional VNTR of IGH enhancer HS1.2 associates with human longevity and interacts with TNFA promoter diplotype in a population of Central Italy.

Gene - 10 Nov 2014

Napolioni Valerio, Serone Eliseo, Iacoacci Valentina, Carpi Francesco M, Giambra Vincenzo, Frezza Domenico

Abstract excerpt

The dysregulation of both immune and inflammatory responses occurring with aging is believed to substantially contribute to morbidity and mortality in humans. We have already reported the association of the functional Variable Number of Tandem Repeat (VNTR) at the Immunoglobulin heavy chain (IGH) enhancer HS1.2 with Immunoglobulin levels and with several autoimmune diseases. Herein we tested the association of...

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PMID: 25175451
DOI: 10.1016/j.gene.2014.08.057

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IGH

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