Article
Ocular Phenotype of Relaxin Gene Knockout (Rln-/-) Mice.
Current eye research - 1 Oct 2020
Hampel Ulrike, Chinnery Holly R, Garreis Fabian, Paulsen Friedrich, de Iongh Robb, Bui Bang V, Nguyen Christine, Parry Laura, Huei Leo Chen
Abstract excerpt
Purpose: To test if relaxin deficiency affects ocular structure and function we investigated expression of relaxin (Rln) and RXFP receptors (Rxfp1, Rxfp2), and compared ocular phenotypes in relaxin gene knockout (Rln-/- ) and wild type (Rln+/+ ) mice. Materials and Methods: Rln, Rxfp1 and Rxfp2 mRNA expression was detected in ocular tissues of Rln+/+ mice using RT-PCR. The eyes of 11 Rln-/- and 5 Rln+/+ male mice...
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