Article
Molecular characterization of the ligand binding site of the human galanin receptor type 2, identifying subtype selective interactions.
Journal of neurochemistry - 1 Dec 2007
Lundström Linda, Sollenberg Ulla E, Bartfai Tamas, Langel Ulo
Abstract excerpt
To define the specific role of the galanin receptors when mediating the effect of galanin, effective tools for distinct activation and inhibition of the different receptor subtypes are required. Several of the physiological effects modulated by galanin are implicated to be mediated via the GalR2 subtype and have been distinguished from GalR1 effects by utilizing the Gal(2-11) peptide, recognizing only GalR2 and...
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