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Article

Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology.

Stem cells translational medicine - 1 May 2016

Selich Anton, Daudert Jannik, Hass Ralf, Philipp Friederike, von Kaisenberg Constantin, Paul Gabi, Cornils Kerstin, Fehse Boris, Rittinghausen Susanne, Schambach Axel, Rothe Michael

Abstract excerpt

UNLABELLED: Mesenchymal stem (or stromal) cells (MSCs) have been used in more than 400 clinical trials for the treatment of various diseases. The clinical benefit and reproducibility of results, however, remain extremely variable. During the in vitro expansion phase, which is necessary to achieve clinically relevant cell numbers, MSCs show signs of aging accompanied by different contributions of single clones to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27034413
DOI: 10.5966/sctm.2015-0176
PMCID: PMC4835246

Genes

MSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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