Article
Alcohol-aggravated episodic pain in humans with SCN11A mutation and ALDH2 polymorphism.
Pain - 1 Jul 2020
Yang Luyao, Li Lulu, Tang Haiyan, Ma Tingbin, Li Yulei, Zhang Xianwei, Shi Xiaoliu, Liu Jing Yu
Abstract excerpt
Mutations in Nav1.9 encoded by SCN11A have been associated with episodic pain, small-fiber neuropathy, and congenital insensitivity to pain. In this study, we collected and characterized one Chinese family with episodic pain. The SCN11A mutation (c.664C>A/p.Arg222Ser) was identified and cosegregated with the episodic pain phenotype. In addition, we found that alcohol intake triggered intense pain attacks and...
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