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Article

Atomic model of a cell-wall cross-linking enzyme in complex with an intact bacterial peptidoglycan.

Journal of the American Chemical Society - 24 Dec 2014

Schanda Paul, Triboulet Sébastien, Laguri Cédric, Bougault Catherine M, Ayala Isabel, Callon Morgane, Arthur Michel, Simorre Jean-Pierre

Abstract excerpt

The maintenance of bacterial cell shape and integrity is largely attributed to peptidoglycan, a highly cross-linked biopolymer. The transpeptidases that perform this cross-linking are important targets for antibiotics. Despite this biomedical importance, to date no structure of a protein in complex with an intact bacterial peptidoglycan has been resolved, primarily due to the large size and flexibility of...

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Identifiers

PMID: 25429710
DOI: 10.1021/ja5105987
PMCID: PMC4544747

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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