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Article

Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.

The EMBO journal - 1 Apr 2020

Xu Jiuzhi, Tang Yang, Sheng Xiaole, Tian Yuhua, Deng Min, Du Sujuan, Lv Cong, Li Guili, Pan Yuwei, Song Yongli, Lou Pengbo, Luo Yongting, Li Yuan, Zhang Bing, Chen Yanmei, Liu Zhanju, Cong Yingzi, Plikus Maksim V, Meng Qingyong, Zhou Zhaocai, Yu Zhengquan

Abstract excerpt

The Hippo-YAP signaling pathway plays an essential role in epithelial cells during intestinal regeneration and tumorigenesis. However, the molecular mechanism linking stromal signals to YAP-mediated intestinal regeneration and tumorigenesis is poorly defined. Here, we report a stroma-epithelium ISLR-YAP signaling axis essential for stromal cells to modulate epithelial cell growth during intestinal regeneration...

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Identifiers

PMID: 32128839
DOI: 10.15252/embj.2019103255
PMCID: PMC7110107

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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