Article
A Genome-wide Association Study of Circulating Levels of Atorvastatin and Its Major Metabolites.
Clinical pharmacology and therapeutics - 1 Aug 2020
Turner Richard M, Fontana Vanessa, Zhang Jieying E, Carr Daniel, Yin Peng, FitzGerald Richard, Morris Andrew P, Pirmohamed Munir
Abstract excerpt
Atorvastatin (ATV) is frequently prescribed and generally well tolerated, but can lead to myotoxicity, especially at higher doses. A genome-wide association study of circulating levels of ATV, 2-hydroxy (2-OH) ATV, ATV lactone (ATV L), and 2-OH ATV L was performed in 590 patients who had been hospitalized with a non-ST elevation acute coronary syndrome 1 month earlier and were on high-dose ATV (80 mg or 40 mg...
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