Statin Lactone Metabolism is a Determinant of 5-year Cardiovascular Outcomes Independent of Serum Cholesterol

Abstract excerpt

<title>Abstract</title> <p>Statins are a first line treatment for reducing cardiovascular risk, however the individual clinical benefit of statins remains highly variable. To understand the clinical impact of individual statin metabolites on long-term clinical outcomes, we conducted a 5-year, multicentre, prospective, observational trial of 1362 cardiology patients across two independent healthcare systems in Sin...

Topics

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• Drug Transport and Resistance Mechanisms
• Genetic Predisposition to Disease
• Genetic Variation
• Genome-Wide Association Study
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Liver-Specific Organic Anion Transporter 1
• Pharmacogenetics and Drug Metabolism
• Precision Medicine

Identifiers and source

Literature Corpus work

a813dd72-c299-5832-a688-54e89f5e0dbb

DOI

10.21203/rs.3.rs-4023614/v1