Article
Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy.
Clinical pharmacology and therapeutics - 1 Jun 2006
Hermann Monica, Bogsrud Martin P, Molden Espen, Asberg Anders, Mohebi Beata U, Ose Leiv, Retterstøl Kjetil
Abstract excerpt
BACKGROUND: The most serious side effect from statin treatment is myopathy, which may proceed to rhabdomyolysis. This is the first study to investigate whether the pharmacokinetics of either atorvastatin or its metabolites, or both, is altered in patients with atorvastatin-related myopathy compared with healthy controls. METHODS: A 24-hour pharmacokinetic investigation was performed in 14 patients with...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 1
- Adult
- Aged
- Anticholesteremic Agents
- Atorvastatin
- Case-Control Studies
- Creatine Kinase
- Creatinine
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme System
- Female
- Genotype
- Heptanoic Acids