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Article

Establishment of a novel human cell line retaining the characteristics of the original pancreatic adenocarcinoma, and evaluation of MEK as a therapeutic target.

International journal of oncology - 1 Mar 2020

Du Xiaoxiao, He Kuifeng, Huang Yingying, Xu Zhenzhen, Kong Mei, Zhang Jing, Cao Jiang, Teng Lisong

Abstract excerpt

Pancreatic cancer is a lethal solid malignancy with limited therapeutic options. The development of novel therapeutic drugs requires adequate new cell line models. A new pancreatic cancer cell line, designated PDXPC1, was established from one pancreatic ductal adenocarcinoma (PDAC) patient‑derived xenograft. The PDXPC1 cells were stably cultured for >2 years and had a stable short tandem repeat profile. The...

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Identifiers

PMID: 32124956
DOI: 10.3892/ijo.2020.4965
PMCID: PMC7010221

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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