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Article

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin.

Journal of translational medicine - 10 May 2016

Hall Jason C, Marlow Laura A, Mathias Adam C, Dawson Louis K, Durham William F, Meshaw Kenneth A, Mullin Robert J, Synnott Aidan J, Small Daniel L, Krishna Murli, von Hoff Daniel, Schüler Julia, Hart Steven N, Couch Fergus J, Colon-Otero Gerardo, Copland John A

Abstract excerpt

BACKGROUND: Pancreatic acinar cell carcinoma (PACC) is a rare malignancy, accounting for <1 % of all pancreatic neoplasms. Very few retrospective studies are available to help guide management. We previously reported the case of a patient with metastatic PACC who achieved prolonged survival following doxorubicin treatment. Personalized treatment was based on molecular and in vitro data collected from primary...

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Identifiers

PMID: 27165126
DOI: 10.1186/s12967-016-0875-z
PMCID: PMC4862141

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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