Article
Establishment and Characterization of Two Novel Human Pancreatic Carcinoma Cell Lines.
Anticancer research - 1 Jul 2015
Hirano Katsuhisa, Okumura Tomoyuki, Shimada Yutaka, Watanabe Toru, Yamaguchi Tetsuji, Nagata Takuya, Tsukada Kazuhiro
Abstract excerpt
BACKGROUND: Pancreatic carcinoma (PC) is among the most lethal types of carcinomas worldwide. We aimed to establish well-defined PC cell lines in order to determine their resistance to chemotherapy. MATERIALS AND METHODS: Cells cultured from the tumors of two patients were analyzed for xenograft formation, V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) and TP53 mutations, chemosensitivity, and mRNAs...
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