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Article

Conservative Evolution of Hepatitis B Virus Precore and Core Gene During Immune Tolerant Phase in Intrafamilial Transmission.

Virologica Sinica - 1 Aug 2020

Luo Yuqian, Zhang Le, Dai Yimin, Hu Yali, Xu Biyun, Zhou Yi-Hua

Abstract excerpt

Hepatitis B virus (HBV) is characterized with high mutations, which is attributed to the lack of proof-reading of the viral reverse transcriptase and host immune pressure. In this study, 31 HBV chronic carriers from 14 families were enrolled to investigate the evolution of the same original HBV sources in different hosts. Sequences of pre-C and C (pre-C/C) genes were analyzed in eight pairs of HBV-infected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32124248
DOI: 10.1007/s12250-020-00194-6
PMCID: PMC7462953

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