Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genomic alterations and abnormal expression of APE2 in multiple cancers.

Scientific reports - 28 Feb 2020

Jensen Katherine A, Shi Xinghua, Yan Shan

Abstract excerpt

Although APE2 plays essential roles in base excision repair and ATR-Chk1 DNA damage response (DDR) pathways, it remains unknown how the APE2 gene is altered in the human genome and whether APE2 is differentially expressed in cancer patients. Here, we report multiple-cancer analyses of APE2 genomic alterations and mRNA expression from cancer patients using available data from The Cancer Genome Atlas (TCGA). We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase
Share to DNA Repair
Share to Endonucleases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Enzymologic

Share to Gene Expression Regulation, Neoplastic

Share to Multifunctional Enzymes

Share to Neoplasm Proteins

Share to Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 32111912
DOI: 10.1038/s41598-020-60656-5
PMCID: PMC7048847

Genes

ATR
PARP1
PCNA
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genomic alterations and abnormal expression of APE2 in multiple cancers.PMID 32111912Read ↗

Genomic alterations and abnormal expression of APE2 in multiple cancersSemantic proximity Read ↗

NPAS2 dampens chemo-sensitivity of lung adenocarcinoma cells by enhancing DNA damage repairSemantic proximity Read ↗

Integrative Bioinformatics Analysis of KPNA2 in Six Major Human CancersSemantic proximity Read ↗

APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinomaSemantic proximity Read ↗

Emerging Roles of DDB2 in CancerSemantic proximity Read ↗

Apurinic/apyrimidinic nuclease 1 drives genomic evolution contributing to chemoresistance and tumorigenesis in solid tumorSemantic proximity Read ↗

ESCO2's Oncogenic Role in Human Tumors: A Pan-Cancer Analysis and Experimental ValidationSemantic proximity Read ↗

APE1 promotes radiation resistance against radiation-induced pyroptosis by inhibiting the STING pathway in lung adenocarcinomaSemantic proximity Read ↗

Multiple skin cancers in adults with mutations in the XP-E (DDB2) DNA repair gene.Semantic proximity Read ↗

Integrated genomics and comprehensive validation reveal novel drivers of genomic evolution in esophageal adenocarcinomaSemantic proximity Read ↗

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation.Semantic proximity Read ↗

Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.