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Article

Macropinocytosis confers resistance to therapies targeting cancer anabolism.

Nature communications - 28 Feb 2020

Jayashankar Vaishali, Edinger Aimee L

Abstract excerpt

Macropinocytic cancer cells scavenge amino acids from extracellular proteins. Here, we show that consuming necrotic cell debris via macropinocytosis (necrocytosis) offers additional anabolic benefits. A click chemistry-based flux assay reveals that necrocytosis provides not only amino acids, but sugars, fatty acids and nucleotides for biosynthesis, conferring resistance to therapies targeting anabolic pathways....

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Share to Antimetabolites, Antineoplastic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32111826
DOI: 10.1038/s41467-020-14928-3
PMCID: PMC7048872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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