Article

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cells

2022-10-17

Abstract excerpt

Mannose has anti-cancer activity that inhibits cell proliferation and enhances the efficacy of chemotherapy. How mannose exerts its anti-cancer activity, however, remains poorly understood. Here, using genetically engineered human cancer cells that permit the precise control of mannose metabolic flux, we demonstrate that the large influx of mannose exceeding its metabolic capacity induced metabolic remodeling, lea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2878a9ed-e2b5-57d8-8c2b-f753da9d3666
DOI: 10.1101/2022.10.17.512485

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Metabolic clogging of mannose triggers genomic instability via dNTP loss in human cancer cellsDOI 10.1101/2022.10.17.512485Read

Rewiring glucose metabolism improves 5-FU efficacy in p53-deficient/KRASG12D glycolytic colorectal tumorsSemantic proximity Read

Metabolic alterations in cancer cells and therapeutic implications.Semantic proximity Read

Rewiring glucose metabolism improves 5-FU efficacy in glycolytic p53-deficient colorectal tumorsSemantic proximity Read

Metabolic hijacking: A survival strategy cancer cells exploit?Semantic proximity Read

Understanding the Warburg effect: the metabolic requirements of cell proliferation.Semantic proximity Read

Bridging the gap: advancing cancer cell culture to reveal key metabolic targetsSemantic proximity Read

Disruption of sugar nucleotide clearance is a therapeutic vulnerability of cancer cellsSemantic proximity Read

Rewiring Glucose Metabolism Improves 5-FU Efficacy in Glycolytic p53-Deficient Colorectal TumorsSemantic proximity Read

Rewiring of the Host Cell Metabolome and Lipidome during Lytic Gammaherpesvirus Infection Is Essential for Infectious-Virus ProductionSemantic proximity Read

A glycolytic metabolite that drives BRCA2 haploinsufficiency.Semantic proximity Read

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides.Semantic proximity Read

The landscape of metabolic pathway dependencies in cancer cell linesSemantic proximity Read