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Single-cell morphological and transcriptome analysis unveil inhibitors of polyploid giant breast cancer cells in vitro

21 Dec 2023

Abstract excerpt

Considerable evidence suggests that breast cancer therapeutic resistance and relapse can be driven by polyploid giant cancer cells (PGCCs). The number of PGCCs increases with the stages of disease and therapeutic stress. Given the importance of PGCCs, it remains challenging to eradicate them. To discover effective anti-PGCC compounds, there is an unmet need to rapidly distinguish compounds that kill non-PGCCs,...

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PMID: 38129519
DOI: 10.1038/s42003-023-05674-5

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