Article
Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.
Atherosclerosis - 1 Mar 2020
Feitosa Mary F, Lunetta Kathryn L, Wang Lihua, Wojczynski Mary K, Kammerer Candace M, Perls Thomas, Schupf Nicole, Christensen Kaare, Murabito Joanne M, Province Michael A
Abstract excerpt
BACKGROUNDS AND AIMS: Several genes are known to contribute to the levels and metabolism of HDL-C, however, their protective effects in cardiovascular disease (CVD), healthy aging, and longevity are complex and poorly understood. It is also unclear if these genes predict longitudinal HDL-C change. We aimed to identify loci influencing HDL-C change. METHODS: We performed a genome-wide association study (GWAS) with...
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