Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

Journal of lipid research - 1 Dec 2008

Lu Yingchang, Dollé Martijn E T, Imholz Sandra, van 't Slot Ruben, Verschuren W M Monique, Wijmenga Cisca, Feskens Edith J M, Boer Jolanda M A

Abstract excerpt

The known genetic variants determining plasma HDL cholesterol (HDL-C) levels explain only part of its variation. Three hundred eighty-four single nucleotide polymorphisms (SNPs) across 251 genes based on pathways potentially relevant to HDL-C metabolism were selected and genotyped in 3,575 subjects from the Doetinchem cohort, which was examined thrice over 11 years. Three hundred fifty-three SNPs in 239 genes...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cholesterol, HDL
Share to ADD1 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to APOA5 gene

Share to LIPC gene

Share to PTPN11 gene

Share to Genetic Variation

Share to Genotype

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 18660489
DOI: 10.1194/jlr.M800232-JLR200

Genes

ADD1
APOA5
CETP
LIPC
LPL
MBTPS2
NRIP1
PTPN11
SCAND1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.PMID 18660489Read ↗

Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.Semantic proximity Read ↗

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.Semantic proximity Read ↗

Genetic-epidemiological evidence on genes associated with HDL cholesterol levels: a systematic in-depth review.Semantic proximity Read ↗

Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci.Semantic proximity Read ↗

Newly identified loci that influence lipid concentrations and risk of coronary artery disease.Semantic proximity Read ↗

Gene discovery for high-density lipoprotein cholesterol level change over time in prospective family studies.Semantic proximity Read ↗

Analysis of multiple association studies provides evidence of an expression QTL hub in gene-gene interaction network affecting HDL cholesterol levels.Semantic proximity Read ↗

Common variants at 30 loci contribute to polygenic dyslipidemia.Semantic proximity Read ↗

LIPC variants in the promoter and intron 1 modify HDL-C levels in a sex-specific fashion.Semantic proximity Read ↗

Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.Semantic proximity Read ↗

Exploring genetic determinants of plasma total cholesterol levels and their predictive value in a longitudinal study.Semantic proximity Read ↗

Common variants of multiple genes that control reverse cholesterol transport together explain only a minor part of the variation of HDL cholesterol levels.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.