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Article

Knowledge-driven multi-locus analysis reveals gene-gene interactions influencing HDL cholesterol level in two independent EMR-linked biobanks.

PloS one - 11 May 2011

Turner Stephen D, Berg Richard L, Linneman James G, Peissig Peggy L, Crawford Dana C, Denny Joshua C, Roden Dan M, McCarty Catherine A, Ritchie Marylyn D, Wilke Russell A

Abstract excerpt

Genome-wide association studies (GWAS) are routinely being used to examine the genetic contribution to complex human traits, such as high-density lipoprotein cholesterol (HDL-C). Although HDL-C levels are highly heritable (h(2)∼0.7), the genetic determinants identified through GWAS contribute to a small fraction of the variance in this trait. Reasons for this discrepancy may include rare variants, structural...

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Share to Cholesterol, HDL
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to APOA1 gene

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Source

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Identifiers

PMID: 21589926
DOI: 10.1371/journal.pone.0019586
PMCID: PMC3092760

Genes

LPL
ABCA1
APOA1
CETP
LIPC
TRIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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