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Article

Impact of RAS mutations on the immune infiltrate of colorectal liver metastases: A preliminary study.

Journal of leukocyte biology - 1 Aug 2020

Polidoro Michela Anna, Milana Flavio, Soldani Cristiana, Franceschini Barbara, Anselmo Achille, Colombo Federico Simone, Di Tommaso Luca, Cimino Matteo, Carnevale Silvia, Lleo Ana, Jaillon Sebastien, Torzilli Guido, Donadon Matteo

Abstract excerpt

Kirsten rat sarcoma viral oncogene homolog KRAS proto-oncogene is the most common altered gene in colorectal cancer (CRC). Determining its mutational status, which is associated with worse prognosis and resistance to anti-epidermal growth factor receptor (EGFR) inhibitors, is essential for managing patients with CRC and colon liver metastases (CLM). Emerging studies highlighted the relationship of KRAS-mutated...

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PMID: 32108374
DOI: 10.1002/JLB.5AB0220-608R

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