Article

Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastases

2022-08-01

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Liver metastases are a major contributor to the poor immunotherapy response in colorectal cancer patients. However, the distinctions in the immune microenvironment between primary tumors and liver metastases are poorly characterized. The goal of this study was to compare the expression profile of multiple immune cells to further analyze the similarities and diffe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 877404e5-3fc8-53b6-a997-33d1fe5417db
DOI: 10.21203/rs.3.rs-1772371/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-perspective comparison of the immune microenvironment of primary colorectal cancer and liver metastasesDOI 10.21203/rs.3.rs-1772371/v1Read

PD-L1 expression in liver metastasis: its clinical significance and discordance with primary tumor in colorectal cancerSemantic proximity Read

Immunoscore encompassing CD3+ and CD8+ T cell densities in distant metastasis is a robust prognostic marker for advanced colorectal cancer.Semantic proximity Read

Integrated Multi-Omics Landscape of Liver Metastases.Semantic proximity Read

Hepatocellular carcinoma (HCC) Tumor microenvironment is more suppressive than colorectal cancer liver metastasis (CRLM) Tumor microenvironment.Semantic proximity Read

Analysis of the immune microenvironment in colorectal cancer with different KRAS gene subtypesSemantic proximity Read

Preliminary Exploration of the Relationship between Tumor Microenvironment in Malignant Ascites and Patient PrognosisSemantic proximity Read

Immunological and Clinico-Molecular Features of Tumor Border Configuration in Colorectal Cancer.Semantic proximity Read

Enrichment of Cancer-Associated Fibroblasts, Macrophages, and Up-Regulated TNF-α Signaling in the Tumor Microenvironment of CMS4 Colorectal Peritoneal Metastasis.Semantic proximity Read

Spatially Resolved Transcriptomics Deconvolutes Histological Prognostic Subgroups in Patients with Colorectal Cancer and Synchronous Liver MetastasesSemantic proximity Read

Establishment and Validation of a Macrophage-Related Model for Predicting Synchronous Distant Metastasis of Colorectal CancerSemantic proximity Read

Role of T cells in liver metastasisSemantic proximity Read

Digital pattern recognition-based image analysis quantifies immune infiltrates in distinct tissue regions of colorectal cancer and identifies a metastatic phenotype.Semantic proximity Read