Shedding LIGHT (TNFSF14) on the tumor microenvironment of colorectal cancer liver metastases.

Abstract excerpt

BACKGROUND: T-cell infiltration in primary colon tumors is associated with improved patient survival. Preliminary data supports a similar association in colorectal liver metastases (CRLM), and we previously identified increased CRLM expression of the immunostimulatory cytokine LIGHT (TNFSF14) to be related to improved patient prognosis. Therefore, mechanisms to augment the T-cell response in CRLM may be a...

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