Article
Intraperitoneal neutrophils activated by KRAS-induced ovarian cancer exert antitumor effects by modulating adaptive immunity.
International journal of oncology - 1 Oct 2018
Yoshida Mitsuyo, Taguchi Ayumi, Kawana Kei, Ogishima Juri, Adachi Katsuyuki, Kawata Akira, Nakamura Hiroe, Sato Masakazu, Fujimoto Asaha, Inoue Tomoko, Tomio Kensuke, Mori Mayuyo, Nagamatsu Takeshi, Arimoto Takahide, Koga Kaori, Hiraike Osamu Wada, Oda Katsutoshi, Kiyono Tohru, Osuga Yutaka, Fujii Tomoyuki
Abstract excerpt
Increased neutrophil counts are a hallmark of a poor prognosis for cancer. We previously reported that KRAS promoted tumorigenesis and increased neutrophil counts in a mouse peritoneal cancer model. In the current study, we evaluated the role of increased neutrophils in cancer progression, as well as their influence on the intraperitoneal microenvironment. A mouse peritoneal cancer model was established using the...
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