Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.

doi:10.1002/hep.27604

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Article

Hepatitis B surface antigen genetic elements critical for immune escape correlate with hepatitis B virus reactivation upon immunosuppression.

Hepatology (Baltimore, Md.) - 1 Mar 2015

Salpini Romina, Colagrossi Luna, Bellocchi Maria Concetta, Surdo Matteo, Becker Christina, Alteri Claudia, Aragri Marianna, Ricciardi Alessandra, Armenia Daniele, Pollicita Michela, Di Santo Fabiola, Carioti Luca, Louzoun Yoram, Mastroianni Claudio Maria, Lichtner Miriam, Paoloni Maurizio, Esposito Mariarosaria, D'Amore Chiara, Marrone Aldo, Marignani Massimo, Sarrecchia Cesare, Sarmati Loredana, Andreoni Massimo, Angelico Mario, Verheyen Jens, Perno Carlo-Federico, Svicher Valentina

Abstract excerpt

UNLABELLED: Hepatitis B virus (HBV) reactivation during immunosuppression can lead to severe acute hepatitis, fulminant liver failure, and death. Here, we investigated hepatitis B surface antigen (HBsAg) genetic features underlying this phenomenon by analyzing 93 patients: 29 developing HBV reactivation and 64 consecutive patients with chronic HBV infection (as control). HBsAg genetic diversity was analyzed by...

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PMID: 25418031
DOI: 10.1002/hep.27604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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