Article
Association between the cytotoxic T-lymphocyte antigen-4 mutations and the susceptibility to systemic lupus erythematosus; Contribution markers of inflammation and oxidative stress.
Cellular and molecular biology (Noisy-le-Grand, France) - 31 Oct 2016
Tanhapour M, Vaisi-Raygani A, Bahrehmand F, Khazaei M, Kiani A, Rahimi Z, Nomani H, Tavilani H, Pourmotabbed T
Abstract excerpt
The cytotoxic T lymphocyte antigen-4 (CTLA-4) also known as CD152 (cluster of differentiation 152) is a crucial negative regulator of the immune system. This protein receptor provides negative signals in order to suppress T-cell activation and immune attack against self-antigens, although its role is unclear. The ability of CTLA-4 to limit T cell-mediated immune response has made it a major target in treatment...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- CTLA-4 Antigen
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Predisposition to Disease