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Article

Whole-exome sequencing study of opioid dependence offers novel insights into the contributions of exome variants.

Translational psychiatry - 6 Oct 2025

Wang Lu, Nuñez Yaira Z, Martínez-Magaña José Jaime, Rivera-Hernandez Melody, Mao Zhongzheng, Brennand Kristen J, Montalvo-Ortiz Janitza L, Kranzler Henry R, Gelernter Joel, Zhou Hang

Abstract excerpt

Opioid dependence (OD) is epidemic in the United States and it is associated with a variety of adverse health effects. Its estimated heritability is ~50% in twin studies, and recent genome-wide association studies have identified more than a dozen common risk variants. However, there are no published studies of rare OD risk variants. In this study, we analyzed whole-exome sequencing data from the Yale-Penn...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41052974
DOI: 10.1038/s41398-025-03578-y
PMCID: PMC12500996

Genes

CFAP44
CHRND
COL3A1
DHX58
FAM90A1
GLDN
GPHB5
NEIL2
PLAT
QPCTL
RUVBL2

Provenance

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