Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein Gene

24 Feb 2020

Abstract excerpt

Lassa virus (LASV) infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever (LF) cases. Licensed LF vaccines are not available, and anti-LF therapy is limited to off-label use of the nucleoside analog ribavirin with uncertain efficacy. We describe the generation of a novel live-attenuated LASV vaccine candidate. This vaccine candidate is based on mutating wild-type (WT) LASV...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to Viral gastroenteritis research and epidemiology
Share to Viral Infections and Outbreaks Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32098811
DOI: 10.1128/mbio.00039-20

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Lassa Fever Live-Attenuated Vaccine Based on Codon Deoptimization of the Viral Glycoprotein GenePMID 32098811Read ↗

A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigsSemantic proximity Read ↗

General Molecular Strategy for Development of Arenavirus Live-Attenuated VaccinesSemantic proximity Read ↗

A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic RegionSemantic proximity Read ↗

Vaccines inducing immunity to Lassa virus glycoprotein and nucleoprotein protect macaques after a single shotSemantic proximity Read ↗

Development of Live-Attenuated Arenavirus Vaccines Based on Codon DeoptimizationSemantic proximity Read ↗

Lassa Virus Vaccine Candidate ML29 Generates Truncated Viral RNAs Which Contribute to Interfering Activity and AttenuationSemantic proximity Read ↗

A codon-pair deoptimized live-attenuated vaccine against respiratory syncytial virus is immunogenic and efficacious in non-human primatesSemantic proximity Read ↗

Enhanced Efficacy of a Codon-Optimized DNA Vaccine Encoding the Glycoprotein Precursor Gene of Lassa Virus in a Guinea Pig Disease Model When Delivered by Dermal ElectroporationSemantic proximity Read ↗

In-silico identification of the vaccine candidate epitopes against the Lassa virus hemorrhagic fever.Semantic proximity Read ↗

Machine Learning Reveals Key Glycoprotein Mutations and Rapidly Assigns Lassa Virus LineagesSemantic proximity Read ↗

Baseline mapping of Lassa fever virology, epidemiology and vaccine research and developmentSemantic proximity Read ↗

A Mutation-Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi-Strains: A Study Using Glycoprotein of LASV.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.