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Article

A Mutation-Based Reverse Vaccinology Approach Considering Variability in Epitopes to Combat Multi-Strains: A Study Using Glycoprotein of LASV.

Journal of cellular and molecular medicine - 1 Oct 2025

Mishra Saurav Kumar, Patil Rajesh B, Sherpa Amdola Tshering, Borhan Uddin Mohammad, Harun-Or-Rashid Md, Ahmed Muniruddin, Dawoud Turki M, Georrge John J

Abstract excerpt

Lassa virus (LASV) remains a persistent threat to public health, and to combat this, various therapeutics have been developed, but their effectiveness is limited due to the virus's strain variability. Therefore, mutation-based reverse vaccinology approaches were implemented to formulate an epitope-based vaccine against the LASV, considering the variability in the glycoprotein. The glycoprotein was examined to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41121599
DOI: 10.1111/jcmm.70907
PMCID: PMC12540218

Genes

GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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