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A Lassa Virus Live-Attenuated Vaccine Candidate Based on Rearrangement of the Intergenic Region

24 Mar 2020

Abstract excerpt

Lassa virus (LASV), the causative agent of Lassa fever, infects several hundred thousand people in Western Africa, resulting in many lethal Lassa fever cases. No U.S. Food and Drug Administration-licensed countermeasures are available to prevent or treat LASV infection. We describe the generation of a novel LASV live-attenuated vaccine candidate rLASV(IGR/S-S), which is based on the replacement of the large...

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PMID: 32209677
DOI: 10.1128/mbio.00186-20

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