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A Lassa virus live attenuated vaccine candidate that is safe and efficacious in guinea pigs

17 Nov 2024

Abstract excerpt

Lassa virus (LASV) is a rodent-borne mammarenavirus that causes tens to hundreds of thousands of human infections annually in Western Africa. Approximately 20% of these infections progress to Lassa fever (LF), an acute disease with case-fatality rates from ≈20-70%. Currently, there are no approved vaccines or specific therapeutics to prevent or treat LF. The LASV genome consists of a small (S) segment that has...

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PMID: 39551823
DOI: 10.1038/s41541-024-01012-w

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